Toxicology MSDT

PRINCIPLES OF GENETIC TOXICOLOGY

​​Topic 2: Different Genetic Damages or Mutations

LEARNING OBJECTIVES
After completing this lesson, you will be able to:
  • Know different types of genetic damages or mutations.
  • Know how different mutations resulted in the cells by mutagens. 

​​Do you know how many mutations or damages are possible by mutagens in the cells?

Mutations can be:
  • Microlesions (gene mutation)
  • Macro lesions  (Chromosomal mutation)

Subtopics: 
​
    2.1. Microlesions (Gene Mutation)
         2.1a. Base-pair substitution mutation  
         2.1b. Frame shift mutation  
    2.2. Macro Lesions  (Chromosomal Mutation)  
         2.2a. Numerical changes in chromosomes  
         2.2b. Structural changes in chromosomes  
         2.2c. Micronuclei changes 

    Key Points & Knowledge Check 


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