Topic 2 Genetic Questions

PRINCIPLES OF GENETIC TOXICOLOGY

Topic 2: Different Genetic Damages or Mutations

LEARNING OBJECTIVES
After completing this lesson, you will be able to:

Know different types of genetic damages or mutations.
Know how different mutations resulted in the cells by mutagens.

Topic 2: Key Points
In this section, we explored the following main points:

Different types of Microlesions (gene mutation) and Macro-lesions (Chromosomal mutation).
How toxic agents or mutagens modulate the two different microlesions namely base pair substitution and frame shift mutation.
Genotoxic mutagens involve also in different macro-lesions namely numerical or structural changes in chromosomes or changes of micronuclei in cell.

Topic 2: Knowledge Check

* Indicates required field

1. In base-pair substitution mutation, single base nucleotide is replaced by another nucleotide. *

A. True B. False

2. Frame shift mutation, resulted to shift or change of entire DNA or amino acid sequence by: *

A. addition of nucleotide in the DNA. B. deletion of nucleotide in the DNA. C. addition or deletion of nucleotide in the DNA

3. What is monosomy? *

A. Duplication of entire set of chromosome . B. single missing chromosome from diploid set. C. three copies of a single chromosome.

4. What are the structural changes in chromosomes caused by toxicants? *

A. Deletion B. Translocation C. Inversion D. Duplication E. All of the above.

5. Micronuclei (MN) changes are the damaged chromosome fragments or whole chromosomes that were not incorporated into the cell nucleus and stayed as the extra-nuclear bodies after the cell division. *

A. True B. False

Check Answers

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PRINCIPLES OF GENETIC TOXICOLOGY

​​Topic 2: Different Genetic Damages or Mutations

​Topic 2: Knowledge Check

Topic 2: Different Genetic Damages or Mutations

Topic 2: Knowledge Check