Toxicology MSDT

PRINCIPLES OF GENETIC TOXICOLOGY

​​Topic 2: Different Genetic Damages or Mutations

LEARNING OBJECTIVES
After completing this lesson, you will be able to:
  • Know different types of genetic damages or mutations.
  • Know how different mutations resulted in the cells by mutagens. 

Topic 2: Key Points
In this section, we explored the following main points:​​
  • Different types of Microlesions (gene mutation) and Macro-lesions (Chromosomal mutation).
  • How toxic agents or mutagens modulate the two different microlesions namely base pair substitution and frame shift mutation.
  • Genotoxic mutagens involve also in different macro-lesions namely  numerical or structural changes in chromosomes or changes of micronuclei in cell.

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    ​Topic 2: Knowledge Check

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