Toxicology MSDT

PRINCIPLES OF GENETIC TOXICOLOGY

​​Subtopic 2.1: Microlesions (Gene Mutation)

  • Microlesions are the damages or mutations in DNA bases.
  • These mutations are with invisible phenotypic changes.
  • Mirco lesions are following types (Figure 1):

2.1a. Base-pair substitution mutation(qualitative change in nucleotide pairs):
  • In this mutation, single base nucleotide is replaced by another nucleotide.

2.1b. Frame shift (quantitative change in nucleotide pairs):
  • ​In this mutation,  addition or deletion of nucleotide in the DNA sequence  resulted to shift or change entire DNA or amino acid sequence.​​​
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Figure 1. Micro lesions mutation by mutagens.
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