Knowledge Check Solutions
1) The toxicant enters the systemic circulatory system after first passing through the liver - This is the correct answer.
Toxicants that enter the vascular system of the gastrointestinal tract are carried directly to the liver by the portal system. Thus, toxicants are immediately subject to biotransformation or excretion by the liver. This is often referred to as the "first pass effect."
1) The toxicant enters the systemic circulatory system after first passing through the liver - This is the correct answer.
Toxicants that enter the vascular system of the gastrointestinal tract are carried directly to the liver by the portal system. Thus, toxicants are immediately subject to biotransformation or excretion by the liver. This is often referred to as the "first pass effect."