Toxicology MSDT

PRINCIPLES OF GENETIC TOXICOLOGY

​​Subtopic 4.5: Proteomics Assay

The proteomic assay is performed to know the mechanism of cellular toxicity by measuring expression of a specific protein which may consider as a biomarker for particular toxic mechanism or cellular toxicity signaling pathway. Immunofluorescence, immunoprecipitation and immunoblot assay  are mainly used to know the effect of toxicants in cellular toxicity signaling pathway or mechanism (Figure 5).
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Figure 5. Schematic presentation of proteomic assay.
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