Toxicology MSDT

BIOCHEMISTRY AND MOLECULAR GENETICS

​​Topic 4: Epigenetic Mechanisms

LEARNING OBJECTIVES
After completing this lesson, you will be able to:
  • ​Identify the main epigenetic mechanisms related to control of gene expression.

Topic 4: Key Points
In this section, we explored the following main points:​
  • Epigenetic mechanisms may influence gene expression without alteration in the DNA sequence.
  • Main epigenetic mechanisms are DNA methylation,  histones post-translational modification and alteration in the expression of microRNAs.
  • Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state.
  • Different from genetic alterations, epigenetic alterations are considered reversible.

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    ​Topic 4: Knowledge Check

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