Subtopic 3.3: Chromosome Aberration Study
Cytogenetic assays of mammalian cells are performed to detect different types of structural and numerical chromosomal aberrations caused by a genotoxic chemicals. The clastogenic or aneugenic effects from the genotoxic chemicals will result an increase in frequency of structural (premature centric separation, chromosome breaks, dicentric chromosomes, ring) complex rearrangements (Figure 4) or numerical aberrations of the genetic material in mammalian cells.
Figure 4. Chromosome aberration study.
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