Section 4: Key Points


What We've Covered
This section made the following main points:
  • Interactions between multiple chemicals can:
    • Decrease toxicity (antagonism).
    • Add to toxicity (additivity).
    • Increase toxicity (synergism or potentiation).
  • Interactions can occur by simultaneous exposure or if exposure to the agents is separated by time.
  • People are normally exposed to many chemicals and combinations of chemicals every day.
  • Emerging approaches in assessing interactions include:
    • Adverse outcome pathways (AOPs).
    • In vitro methods.
    • "Omics" techniques.
    • In silico approaches.