Knowledge Check Solutions
1) Randomize the selected test animals - This is the correct answer.
The Three Rs involve replacing animals in science by in vitro, in silico, and other approaches; reducing the number of animals used in testing; and refining care and procedures to minimize pain and distress.
2) Compare the therapeutically effective dose to the toxic dose of a pharmaceutical agent - This is the correct answer.
The Therapeutic Index (TI) is used to compare the therapeutically effective dose to the toxic dose of a pharmaceutical agent.
3) Ratio of the Toxic Dose to 1% of the population (TD01) to the Effective Dose to 99% of the population (ED99) - This is the correct answer.
The Margin of Safety (MOS) is the ratio of the Toxic Dose to 1% of the population (TD01) to the Effective Dose to 99% of the population (ED99).
4) Highest dose at which there was no observed toxic or adverse effect - This is the correct answer.
The No Observed Adverse Effect Level (NOAEL) is the highest dose at which there was no observed toxic or adverse effect.
5) Lowest dose at which there was an observed toxic or adverse effect - This is the correct answer.
The Lowest Observed Adverse Effect Level (LOAEL) is the lowest dose at which there was an observed toxic or adverse effect.
1) Randomize the selected test animals - This is the correct answer.
The Three Rs involve replacing animals in science by in vitro, in silico, and other approaches; reducing the number of animals used in testing; and refining care and procedures to minimize pain and distress.
2) Compare the therapeutically effective dose to the toxic dose of a pharmaceutical agent - This is the correct answer.
The Therapeutic Index (TI) is used to compare the therapeutically effective dose to the toxic dose of a pharmaceutical agent.
3) Ratio of the Toxic Dose to 1% of the population (TD01) to the Effective Dose to 99% of the population (ED99) - This is the correct answer.
The Margin of Safety (MOS) is the ratio of the Toxic Dose to 1% of the population (TD01) to the Effective Dose to 99% of the population (ED99).
4) Highest dose at which there was no observed toxic or adverse effect - This is the correct answer.
The No Observed Adverse Effect Level (NOAEL) is the highest dose at which there was no observed toxic or adverse effect.
5) Lowest dose at which there was an observed toxic or adverse effect - This is the correct answer.
The Lowest Observed Adverse Effect Level (LOAEL) is the lowest dose at which there was an observed toxic or adverse effect.