Knowledge Check Solutions
1) The total dose is the quantity of a substance administered to an individual over a period of time or in several individual doses. It is particularly important when evaluating cumulative poisons.
2) Fractionation of a total dose so that the total amount administered is given over a period of time usually results in decreased toxicity. This applies to most forms of toxicity but not necessarily to carcinogenicity or mutagenicity.
3) The usual dosage unit that incorporates the amount of material administered or absorbed in accordance with the size of the individual over a period of time is mg/kg/day. In some cases, much smaller dosage units, such as µg/kg/day, are used.
4) The threshold dose is the dose at which a toxic effect is first encountered.
5) All of these answers are correct. The dose-response relationship demonstrates whether any effect has occurred, the threshold dose, and the rate at which the effect increases with increasing dose levels.
1) The total dose is the quantity of a substance administered to an individual over a period of time or in several individual doses. It is particularly important when evaluating cumulative poisons.
2) Fractionation of a total dose so that the total amount administered is given over a period of time usually results in decreased toxicity. This applies to most forms of toxicity but not necessarily to carcinogenicity or mutagenicity.
3) The usual dosage unit that incorporates the amount of material administered or absorbed in accordance with the size of the individual over a period of time is mg/kg/day. In some cases, much smaller dosage units, such as µg/kg/day, are used.
4) The threshold dose is the dose at which a toxic effect is first encountered.
5) All of these answers are correct. The dose-response relationship demonstrates whether any effect has occurred, the threshold dose, and the rate at which the effect increases with increasing dose levels.